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Ligers, the result of a male lion and female tiger mating, are the biggest of the big cats due to the lack of growth-inhibiting genes in female tigers, which would otherwise counteract the growth-promoting genes of male lions.

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Fun Fact:

Ligers, the result of a male lion and female tiger mating, are the biggest of the big cats due to the lack of growth-inhibiting genes in female tigers, which would otherwise counteract the growth-promoting genes of male lions.

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britannica.com

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